Clinical characteristics and predictors of mortality in patients with melioidosis: the Kapit experience

Objectives Melioidosis, caused by Burkholderia pseudomallei, is prevalent in rural areas of Malaysia. The aim this study to delineate the epidemiology and predictors mortality from melioidosis Kapit district, Sarawak. Methods For retrospective patients with culture-confirmed admitted Hospital, Sarawak, Malaysia, between July 2016 2019, epidemiological, clinical microbiological data were obtained. Univariate multivariate logistic regression analyses used determine mortality. Results Seventy three met inclusion criteria. Diabetes mellitus (28.8%) hypertension (27.4%) primary co-morbidities. Clinical spectrum ranged bacteraemia (64.4%), pneumonia (61.6%) internal organ abscesses (49.3%) localised soft tissue (21.9%) joint (6.9%). Mortality rate was 12.3%. Bacteraemia significantly associated septic shock, whereas tended present a milder form without shock. Septic mechanical ventilation, intensive care unit admission, serum urea, creatinine, bicarbonate, albumin aspartate transaminase all increased on univariate analysis (all P < 0.05). Multivariate revealed that low bicarbonate (P = 0.004, OR 0.64, 95% CI 0.48-0.87) 0.031, 0.73, 0.54–0.97) could be higher Conclusion Melioidosis remains fatal infection commonly presents pneumonia. Two routine parameters, albumin, may have important prognostic implications septicaemic melioidosis.